Stress On The Central Role Of Nucleic Acids And Proteins In Living Cells: Biological Oxidation And Intermediary Metabolism Of Carbohydrates, Lipids, And Proteins, And The General Properties Of Enzymes And Enzyme Catalyzed Reactions In The Intact Cell And Cell-Free Systems. Laboratory Work Stresses Use Of Modern Techniques Used In Biochemical Analysis And In EnzymeAssays. Selected Experiments To Demonstrate The Dynamic Aspects Of Biochemistry In Living Cells And In Cell-Free Systems.Prerequisite: BIO 166 And BIO 167 And BIO 238 And One BIO CourseAt 200 Level Or Above (Not BIO 230) And CHE 234 And CHE 235.

Chemistry and functions of constituents of cells and tissues and the chemical and physical-chemical basis for the structures of nucleic acids, proteins, lipids, and carbohydrates. Basic enzymology and biochemical reaction mechanisms involved in macromolecular synthesis and degradation, transport, and movement. General metabolism of carbohydrates, fats, and nitrogen-containing materials such as amino acids, proteins, and related compounds. Genetic information flow and the regulation of gene expression. In addition, this one-semester biochemistry course also serves as preparation for the MCAT and other professional standardized exams.

Molecular aspects of cellular function; properties of biomolecules, their biosynthesis and breakdown; structure and function of proteins and enzymes, metabolites, membranes and nucleic acids; cellular mechanisms of energy transduction; integration and control of cell metabolism. Experiments cover a variety of modern techniques in biological chemistry.

This course adopts an interdisciplinary approach to understanding the fundamentals of biochemistry, including an introduction to the basic concepts and most common research methods. The focus will be upon the major macromolecules and chemical properties of the living systems. The goal is the development of an integrated appreciation of how biomolecules act and interact to catalyze reactions, to synthesize and degrade biomolecules, and utilize or release energy. Both catabolic and biosynthetic pathways will be discussed. The biochemistry underlying the conversion of information contained in DNA to cellular macromolecules through replication, transcription and translation will be covered. Primary topics include the structure, function, and metabolism of amino acids, proteins, carbohydrates, nucleic acids and lipids; the physical properties of water, pH, buffers and enzyme kinetics; DNA replication and gene regulation.